NAD+ Triple Action Nicotinamide Riboside (NR) 1000mg, Resveratrol 200mg, Quercetin 100mg

Certain genes regulate sirtuins, which are crucial for aging-related processes like DNA repair, inflammation regulation, and metabolism. Genetic variations in SIRT1 or other sirtuins can impact how well the body maintains NAD+ levels and uses it for cellular repair, potentially affecting lifespan and age-related disease susceptibility.

Exercise, diet, and sleep influence sirtuin activity by modulating NAD+ levels. For instance, exercise increases the production of NAMPT, an enzyme involved in NAD+ biosynthesis, which in turn activates sirtuins like SIRT1. A nutrient-rich diet can also support NAD+ and enhance sirtuin function, promoting longevity, improved metabolism, and cellular repair.

Exposure to environmental stressors like UV radiation and pollution can
increase DNA damage, which activates sirtuins to repair cells. However, these stressors also consume
NAD+, reducing its availability for sirtuin activity. Maintaining NAD+ levels through a healthy
environment can help ensure that sirtuins remain active and effective in countering cellular damage.

Chronic inflammation reduces NAD+ levels, which in turn impacts sirtuin activity. Sirtuins
play a key role in modulating inflammation, and when NAD+ is depleted, their ability to control
inflammatory responses is compromised. Maintaining healthy NAD+ levels supports sirtuin-mediated
regulation of inflammation, potentially slowing the aging process.

Hormones like insulin, estrogen, and testosterone influence sirtuin activity. For
example, SIRT1 is known to be involved in regulating insulin sensitivity, while estrogen has been shown
to enhance sirtuin activity, particularly in females. Hormonal imbalances that reduce NAD+ synthesis can
impair sirtuin function, contributing to age-related conditions like metabolic disorders.

Sirtuins, which depend on NAD+, help regulate key cellular functions
like DNA repair, mitochondrial function, and autophagy. Asmitochondrial function declines with age,
sirtuin activity, particularly SIRT1, becomes crucial for maintaining energy production and reducing
oxidative stress. Reduced NAD+ availability can lead to diminished sirtuin activity, accelerating aging.

Stress and social isolation can affect behaviors like sleep, exercise, and
nutrition, which in turn influence sirtuin activity. High levels of stress can reduce NAD+ levels, impairing sirtuins like SIRT1 that regulate stress responses and protect against cellular damage. Positive social interactions and mental health support can help maintain sirtuin function by promoting healthier lifestyle choices.

Chronic diseases like diabetes and neurodegenerative
disorders reduce NAD+ levels, impairing sirtuin activity. For example, SIRT1 helps protect against
neurodegeneration by promoting DNA repair and regulating inflammation. As NAD+ declines, sirtuin
activity decreases, worsening the progression of these diseases and contributing to the aging process.

Epigenetic changes can influence sirtuin expression and function. Sirtuins themselves regulate epigenetic modifications by modifying histones, which affects gene expression related to aging, stress resistance, and metabolism. When NAD+ levels drop with age, sirtuins are less able to regulate these epigenetic changes, which can lead to age-related gene expression patterns.

The wear-and-tear theory and programmed theories of aging both recognize the importance of sirtuins in mitigating the effects of aging. Sirtuins help repair cellular damage and regulate metabolic processes, but as NAD+ levels decline with age, their activity decreases, leading to the accumulation of cellular damage. This depletion of NAD+ and sirtuin activity is thought to
contribute to the aging process and age-related diseases.

NAD+ is essential for DNA repair, particularly through enzymes like PARP that use NAD+ to fix DNA damage. As we age, DNA damage accumulates, and the body's repair capacity declines, leading to NAD+ depletion. This reduces the availability of NAD+ for other functions like sirtuin activation,
further impairing cellular health. Efficient DNA repair is crucial for longevity, and maintaining NAD+ levels supports this process, helping to prevent mutations and cellular dysfunction that contribute to aging. Reduced NAD+ availability hampers repair, accelerating the aging process.